Quantitative Trait Loci Mapping for Porcine Backfat Thickness

Wu, X. L.; Lee, C.; Jiang, J.; Peng, Y. L.; Yan, H. F.; Yang, S. L.; Xiao, B. N.; Liu, X. C.; Shi, Q. S.

doi:2002.15.7.932

Article

Animal Breeding and Genetics

Asian-Australasian Journal of Animal Sciences 2002;15(7): 932-937.
https://doi.org/10.5713/ajas.2002.932 Published online January 1, 2002.

Quantitative Trait Loci Mapping for Porcine Backfat Thickness

X. L. Wu, C. Lee, J. Jiang, Y. L. Peng, H. F. Yan, S. L. Yang, B. N. Xiao, X. C. Liu, Q. S. Shi

Abstract

A partial genome scan using porcine microsatellites was carried out to detect quantitative trait loci (QTL) for backfat thickness (BFT) in a pig reference population. This population carried QTL on chromosomes 1, 13 and 18. The QTL on chromosome 1 was located between marker loci S0113 and SW1301. The QTL corresponded to very low density lipoprotein receptor gene (VLDLR) in location and in biological effects, suggesting that VLDLR might be a candidate gene. The QTL found on chromosome 13 was found between marker loci SWR1941 and SW864, but significance for the marker-trait association was inconsistent by using data with different generations. The QTL on chromosome 18 was discovered between markers S0062 and S0117, and it was in proximity of the regions where IGFBP3 and GHRHR were located. The porcine obese gene might be also a candidate gene for the QTL on chromosome 18. In order to understand genetic architecture of BFT better, fine mapping and positional comparative candidate gene analyses are necessary

Keywords: Backfat; Genome Scan; Microsatellites; QTL; Pigs