Associations of T→A Mutation in the Promoter Region of Myostatin Gene with Birth Weight in Yorkshire Pigs

Jiang, Y-L; Li, N; Fan, X-Z; Xiao, L-R; Xiang, R-L; Hu, X-X; Du, L-X; Wu, C-X

doi:2002.15.11.1543

Article

Animal Breeding and Genetics

Asian-Australasian Journal of Animal Sciences 2002;15(11): 1543-1545.
https://doi.org/10.5713/ajas.2002.1543 Published online January 1, 2002.

Associations of T→A Mutation in the Promoter Region of Myostatin Gene with Birth Weight in Yorkshire Pigs

Y-L Jiang, N Li, X-Z Fan, L-R Xiao, R-L Xiang, X-X Hu, L-X Du, C-X Wu

Abstract

A T->A mutation in the promoter region of porcine myostatin (MSTN) gene has been identified in our previous work. This study analyzed the associations of the myostatin genotypes (TT, TA) caused by this mutation with birth weigh in Yorkshire pigs. Data from 211 unrelated individuals were collected three times from one breeding farm. Detections of the mutation were carried out by PCR-RFLPs approach. The effects of MSTN genotypes (TT and TA) on birth weight were compared by least square means. The results showed that for birth weight of Yorkshire pigs, individuals with TA genotype were significantly higher than those with TT genotype (p<0.05), and the birth weight for pigs with TA genotype were 1.37 kg in average but only 1.25 kg for pigs with TT genotype, indicating a positive effect of birth weight for A allele.

Keywords: Pig; Myostatin Gene; Mutation; Birth Weight