Bai X, Ma D, Liu A, Shen X, Wang QJ, Liu Y, Jiang Y. 2007. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 318:977–980.
Bulgakov OV, Eggenschwiler JT, Hong DH, Anderson KV, Li T. 2004. FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development 131:2149–2159.
Castro AF, Rebhun JF, Clark GJ, Quilliam LA. 2003. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin-and farnesylation-dependent manner. J Biol Chem 278:32493–32496.
Kang CB, Feng L, Chia J, Yoon HS. 2005. Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2. Biochem Biophys Res Commun 337:30–38.
Lam E, Martin M, Wiederrecht G. 1995. Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. Gene 160:297–302.
Liu JO. 2003. Endogenous protein inhibitors of calcineurin. Biochem Biophys Res Commun 311:1103–1109.
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. 2005. Rheb binds and regulates the mTOR kinase. Curr Biol 15:702–713.
Maestre-Martínez M, Edlich F, Jarczowski F, Weiwad M, Fischer G, Lücke C. 2006. Solution structure of the FK506-binding domain of human FKBP38. J. Biomol NMR 34:197–202.
Nakagawa T, Shirane M, Iemura S, Natsume T, Nakayama KI. 2007. Anchoring of the 26S proteasome to the organellar membrane by FKBP38. Genes Cells 12:709–719.
Nielsen JV, Mitchelmore C, Pedersen KM, Kjaerulff KM, Finsen B, Jensen NA. 2004. Fkbp8: novel isoforms, genomic organization, and characterization of a forebrain promoter in transgenic mice. Genomics 83:181–192.
Sarbassov D, Ali SM, Sabatini DM. 2005. Growing roles for the mTOR pathway. Curr Opin Cell Biol 17:596–603.
Shirane M, Nakayama KI. 2003. Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Nat Cell Biol 5:28–37.
Shirane M, Ogawa MM, Motoyama J, Nakayama KI. 2008. Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse. Genes Cells 13:635–651.
Uhlenbrock K, Weiwad M, Wetzker R, Fischer G, Wittinghofer A, Rubio I. 2009. Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway. FEBS Lett 583:965–970.
Wang HQ, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI. 2005. Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Hum Mol Genet 14:1889–1902.
Weiwad M, Edlich F, Erdmann F, Jarczowski F, Kilka S, Dorn M, Pechstein A, Fischer G. 2005. A reassessment of the inhibitory capacity of human FKBP38 on calcineurin. FEBS Lett 579:1591–1596.
Wong RLY, Wlodarczyk BJ, Min KS, Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP, Finnell RH. 2008. Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Hum Mol Genet 17:587–601.